Publicaciones científicas
Producción científica de los grupos del IMIPP en el período 2021–2026. Reúne los trabajos en los que participa al menos un integrante del instituto; cada título enlaza al artículo original.
2026
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[Clinical and immunological evaluation of patients with inborn errors of immunity after hematopoietic cell transplantation]
Arch Argent Pediatr · DOI: 10.5546/aap.2026-11024 · PubMed -
A serological method's ability to distinguish treatment regimens by assessing early antibody decline in Chagas patients: insights from E1224 data
J Infect Dis · DOI: 10.1093/infdis/jiag427 · PubMed -
Sífilis congénitaReporte de caso
Acquired Syphilis in a Family Cluster Without Evidence of Sexual Transmission
Actas Dermosifiliogr · DOI: 10.1016/j.ad.2026.104654 · PubMed -
Analysis of Tonsillar NK Cell Markers in Pediatric Epstein-Barr Virus (EBV) Asymptomatic Infection and EBV-Associated Hodgkin Lymphoma
Viruses · DOI: 10.3390/v18060667 · PubMed -
Conjugates of α-d-Galp-(1→3)-β-d-Galp for the serological diagnosis of Chagas disease
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0013728 · PubMed -
Consensus framework for developing a target product profile of real-time PCR in Chagas disease therapeutic monitoring
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0014452 · PubMed -
Epstein-BarrEditorial
Editorial: EBV strategies to counteract the immune response
Front Immunol · DOI: 10.3389/fimmu.2026.1895384 · PubMed -
Epstein-BarrEditorial
Editorial: Immune response in EBV infection: from persistence to viral-associated tumours
Front Immunol · DOI: 10.3389/fimmu.2026.1816022 · PubMed -
Epstein-BarrRevisión
Hit-and-run hypothesis: revisiting the impact of EBV in malignancies
Front Immunol · DOI: 10.3389/fimmu.2026.1742214 · PubMed -
Identification of Antifungal Agents AR-12 and Fosmanogepix as Anti-Trypanosoma cruzi Drugs through an Enhanced Fluorogenic β-Galactosidase Phenotypic Screening Assay
ACS Infect Dis · DOI: 10.1021/acsinfecdis.5c00900 · PubMed -
Identification of Trypanosoma cruzi Discrete Typing Units by Multiplex Real-Time PCR
Methods Mol Biol · DOI: 10.1007/978-1-0716-4848-3_8 · PubMed -
Sífilis congénitaPreprint
Lineage-specific tprK diversification and Treponema pallidum transmission dynamics in Buenos Aires, Argentina
bioRxiv · DOI: 10.64898/2026.01.29.702707 · PubMed -
Pediatric Chagas disease
CMAJ · DOI: 10.1503/cmaj.153680-l · PubMed -
Quantitative Real-Time PCR for Trypanosoma cruzi Infection Diagnosis and Treatment Response Monitoring of Patients with Chagas Disease
Methods Mol Biol · DOI: 10.1007/978-1-0716-4848-3_11 · PubMed -
ChagasRevisión
Target product profile for the development of pediatric formulations of new drugs for the treatment of children with T. cruzi infection
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0013597 · PubMed -
Tonsillar Microbial Signature of Fusobacterium nucleatum Associated With Epstein-Barr Virus Latency
J Med Virol · DOI: 10.1002/jmv.70808 · PubMed -
Sífilis congénitaPreprint
Treponema pallidum subsp. pallidum genetic population structure and relevance to syphilis prevention and treatment
medRxiv · DOI: 10.64898/2026.04.27.26351061 · PubMed
2025
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A Comparative Genomic Analysis of Epstein-Barr Virus Strains with a Focus on EBV2 Variability
Int J Mol Sci · DOI: 10.3390/ijms26062708 · PubMed -
An integrated approach to molecular profiling supports precision diagnosis of pediatric medulloblastoma in Argentina amid the resource-constrained setting
Sci Rep · DOI: 10.1038/s41598-025-31809-1 · PubMed -
Co-expression of PD1+ and HLA-DR+ in CD8+ T cells is increased in tonsils of children with EBV primary and persistent infection
Front Immunol · DOI: 10.3389/fimmu.2025.1653165 · PubMed -
Congenital Chagas disease: A cohort study to assess molecular diagnostic methods at the Chagas disease national reference center of Argentina
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0012785 · PubMed -
Differential expression of proliferation and immune response genes between children and adults influences survival of diffuse large B cell lymphoma
Sci Rep · DOI: 10.1038/s41598-025-04349-x · PubMed -
Extracellular vesicles derived microRNAs as non-invasive markers of liver fibrosis in chronically infected HCV patients: a pilot study
Noncoding RNA Res · DOI: 10.1016/j.ncrna.2025.03.004 · PubMed -
Molecular Characterization of Treponema pallidum pallidum in an Adolescent With Syphilitic Hepatitis
Pediatr Infect Dis J · DOI: 10.1097/INF.0000000000004611 · PubMed -
Novel IgM-based lateral flow assay for diagnosis of congenital Chagas disease
Infect Dis (Lond) · DOI: 10.1080/23744235.2025.2468819 · PubMed -
Pandemic-Driven Shifts in Epstein-Barr Virus (EBV) Epidemiology: Single Center Study
Viruses · DOI: 10.3390/v17030375 · PubMed -
Prevalent genetic alterations in pediatric thyroid carcinoma: Insights from an Argentinean study
PLoS One · DOI: 10.1371/journal.pone.0323271 · PubMed -
ChagasRevisión
Redefining the treatment of Chagas disease: a review of recent clinical and pharmacological data for a novel formulation of nifurtimox
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0012849 · PubMed
2024
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Adverse events associated with benznidazole treatment for Chagas disease in children and adults
Br J Clin Pharmacol · DOI: 10.1111/bcp.16214 · PubMed -
An α-Gal antigenic surrogate as a biomarker of treatment evaluation in Trypanosoma cruzi-infected children. A retrospective cohort study
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0011910 · PubMed -
InmunidadReporte de caso
Case Report: Common variable immunodeficiency phenotype and granulomatous-lymphocytic interstitial lung disease with a novel SOCS1 variant
Front Pediatr · DOI: 10.3389/fped.2024.1423858 · PubMed -
ChagasEnsayo clínico
Early assessment of antibodies decline in Chagas patients following treatment using a serological multiplex immunoassay
Nat Commun · DOI: 10.1038/s41467-024-54910-x · PubMed -
HepatopatíasEditorial
Editorial: Precision medicine in viral hepatitis: progress and prospects towards elimination
Front Cell Infect Microbiol · DOI: 10.3389/fcimb.2024.1378423 · PubMed -
ChagasEnsayo clínico
Efficacy and safety of fexinidazole for treatment of chronic indeterminate Chagas disease (FEXI-12): a multicentre, randomised, double-blind, phase 2 trial
Lancet Infect Dis · DOI: 10.1016/S1473-3099(23)00651-5 · PubMed -
Efficacy of short-course treatment for prevention of congenital transmission of Chagas disease: A retrospective cohort study
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0011895 · PubMed -
ChagasEnsayo clínico
Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial
Lancet Infect Dis · DOI: 10.1016/S1473-3099(23)00629-1 · PubMed -
Epstein Barr Virus (EBV) Latent Membrane Protein 1 (LMP-1) Regulates Functional Markers in Intermediate and Non-Classical Monocytes
Cancers (Basel) · DOI: 10.3390/cancers16244169 · PubMed -
Presence of Epstein-Barr virus (EBV) antigens detected by sensitive methods has no influence on local immune environment in diffuse large B cell lymphoma
Cancer Immunol Immunother · DOI: 10.1007/s00262-023-03617-x · PubMed -
Tonsillar cytotoxic CD4 T cells are involved in the control of EBV primary infection in children
Sci Rep · DOI: 10.1038/s41598-024-52666-4 · PubMed
2023
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InmunidadReporte de caso
Case report: De novo SAMD9L truncation causes neonatal-onset autoinflammatory syndrome which was successfully treated with hematopoietic stem cell transplantation
Front Pediatr · DOI: 10.3389/fped.2023.1108207 · PubMed -
Clinical use of molecular methods for Trypanosoma cruzi infection in endemic and non-endemic countries: Benefits, limitations and challenges
Front Parasitol · DOI: 10.3389/fpara.2023.1241154 · PubMed -
Deep serological profiling of the Trypanosoma cruzi TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0011542 · PubMed -
EBV Impact in Peripheral Macrophages' Polarization Cytokines in Pediatric Patients
Viruses · DOI: 10.3390/v15102105 · PubMed -
ChagasEnsayo clínico
Efficacy and Safety of Nifurtimox in Pediatric Patients with Chagas Disease: Results at 4-Year Follow-Up in a Prospective, Historically Controlled Study (CHICO SECURE)
Antimicrob Agents Chemother · DOI: 10.1128/aac.01193-22 · PubMed -
ChagasEnsayo clínico
ELISA F29 -A therapeutic efficacy biomarker in Chagas disease: Evaluation in pediatric patients treated with nifurtimox and followed for 4 years post-treatment
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0011440 · PubMed -
Expression of EBV-encoded genes in children with asymptomatic infection detected by sensitive methods
Virology · DOI: 10.1016/j.virol.2023.109847 · PubMed -
Major benznidazole metabolites in patients treated for Chagas disease: Mass spectrometry-based identification, structural analysis and detoxification pathways
Toxicol Lett · DOI: 10.1016/j.toxlet.2023.02.001 · PubMed -
MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infected
J Mol Med (Berl) · DOI: 10.1007/s00109-023-02367-8 · PubMed -
Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0010850 · PubMed -
Presence of EBV antigens detected by a sensitive method in pediatric and adult Diffuse Large B-cell lymphomas
Int J Cancer · DOI: 10.1002/ijc.34623 · PubMed -
The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas
Nat Commun · DOI: 10.1038/s41467-023-37522-9 · PubMed -
Toward Global Viral Hepatitis Eradication by 2030: Challenges and Strategies
Rev Argent Microbiol · DOI: 10.1016/j.ram.2023.11.004 · PubMed
2022
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ChagasReporte de caso
[Patient with pulmonary cysts and diagnosis of co-infection with tuberculosis and hydatidosis. Pediatric cases report]
Arch Argent Pediatr · DOI: 10.5546/aap.2022.e272 · PubMed -
Characterization of High-Risk HPV/EBV Co-Presence in Pre-Malignant Cervical Lesions and Squamous Cell Carcinomas
Microorganisms · DOI: 10.3390/microorganisms10050888 · PubMed -
Epstein-BarrEditorial
Editorial: Epstein-Barr virus and its contribution to pediatric tumors
Front Oncol · DOI: 10.3389/fonc.2022.1026366 · PubMed -
Effectiveness of Nifurtimox in the Treatment of Chagas Disease: a Long-Term Retrospective Cohort Study in Children and Adults
Antimicrob Agents Chemother · DOI: 10.1128/aac.02021-21 · PubMed -
Evaluation of Toxoplasma gondii recombinant antigens for early diagnosis of congenital toxoplasmosis
Diagn Microbiol Infect Dis · DOI: 10.1016/j.diagmicrobio.2021.115608 · PubMed -
ChagasEnsayo clínico
Genetic polymorphism of Trypanosoma cruzi bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial
J Antimicrob Chemother · DOI: 10.1093/jac/dkab446 · PubMed -
ChagasReporte de caso
Guillain-Barré Syndrome Associated With Acute Toxoplasmosis in a 3-Year-old Boy
Pediatr Infect Dis J · DOI: 10.1097/INF.0000000000003550 · PubMed -
Intrahepatic immune infiltrate in chronic hepatitis B and chronic hepatitis C: Similar but not the same
J Viral Hepat · DOI: 10.1111/jvh.13635 · PubMed -
Long-term cardiology outcomes in children after early treatment for Chagas disease, an observational study
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0010968 · PubMed -
M1 Macrophage Polarization Prevails in Epstein-Barr Virus-Infected Children in an Immunoregulatory Environment
J Virol · DOI: 10.1128/JVI.01434-21 · PubMed -
Miltefosine and Benznidazole Combination Improve Anti-Trypanosoma cruzi In Vitro and In Vivo Efficacy
Front Cell Infect Microbiol · DOI: 10.3389/fcimb.2022.855119 · PubMed -
Molecular alterations in the integrated diagnosis of pediatric glial and glioneuronal tumors: A single center experience
PLoS One · DOI: 10.1371/journal.pone.0266466 · PubMed -
Multilocus sequence typing of Treponema pallidum pallidum in children with acquired syphilis by nonsexual contact
Future Microbiol · DOI: 10.2217/fmb-2022-0064 · PubMed -
PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival
Front Oncol · DOI: 10.3389/fonc.2022.957208 · PubMed -
PD-L1 is upregulated in CD163+ tonsillar macrophages from children undergoing EBV primary infection
Front Immunol · DOI: 10.3389/fimmu.2022.940910 · PubMed -
InmunidadReporte de caso
Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
J Leukoc Biol · DOI: 10.1002/JLB.5MR0622-037R · PubMed -
ChagasRevisión
Review of pharmacological options for the treatment of Chagas disease
Br J Clin Pharmacol · DOI: 10.1111/bcp.14700 · PubMed -
STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis
J Allergy Clin Immunol · DOI: 10.1016/j.jaci.2022.04.011 · PubMed -
The performance of soluble CD163 as a non-invasive biomarker of liver damage in chronically HCV and HCV/HIV infected subjects
PLoS One · DOI: 10.1371/journal.pone.0270911 · PubMed
2021
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[Argentine consensus of congenital toxoplasmosis]
Medicina (B Aires) · PubMed -
Acquired Syphilis by Nonsexual Contact in Childhood
Pediatr Infect Dis J · DOI: 10.1097/INF.0000000000003215 · PubMed -
Epstein-BarrRevisión
Advances in the Pathogenesis of EBV-Associated Diffuse Large B Cell Lymphoma
Cancers (Basel) · DOI: 10.3390/cancers13112717 · PubMed -
Adverse Events Associated with Nifurtimox Treatment for Chagas Disease in Children and Adults
Antimicrob Agents Chemother · DOI: 10.1128/AAC.01135-20 · PubMed -
ChagasEnsayo clínico
Biopharmaceutical Characteristics of Nifurtimox Tablets for Age- and Body Weight-Adjusted Dosing in Patients With Chagas Disease
Clin Pharmacol Drug Dev · DOI: 10.1002/cpdd.871 · PubMed -
Chronic Hepatitis C Pathogenesis: Immune Response in the Liver Microenvironment and Peripheral Compartment
Front Cell Infect Microbiol · DOI: 10.3389/fcimb.2021.712105 · PubMed -
Comprehensive Evolutionary Analysis of Complete Epstein-Barr Virus Genomes from Argentina and Other Geographies
Viruses · DOI: 10.3390/v13061172 · PubMed -
Congenital chagas disease: Development and assessment of a specific IgM capture-based assay for diagnosis of transmission
Acta Trop · DOI: 10.1016/j.actatropica.2020.105738 · PubMed -
Congenital syphilis in Argentina: Experience in a pediatric hospital
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0009010 · PubMed -
Diagnostic Accuracy of Two Molecular Tools for Diagnosis of Congenital Chagas Disease
Mol Diagn Ther · DOI: 10.1007/s40291-021-00553-3 · PubMed -
Differential tissue distribution of discrete typing units after drug combination therapy in experimental Trypanosoma cruzi mixed infection
Parasitology · DOI: 10.1017/S0031182021001281 · PubMed -
Epstein-Barr virus recruits PDL1-positive cells at the microenvironment in pediatric Hodgkin lymphoma
Cancer Immunol Immunother · DOI: 10.1007/s00262-020-02787-2 · PubMed -
Evaluation of the Chagas Western Blot IgG Assay for the Diagnosis of Chagas Disease
Pathogens · DOI: 10.3390/pathogens10111455 · PubMed -
Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non-alcoholic fatty liver disease
Sci Rep · DOI: 10.1038/s41598-021-84674-z · PubMed -
Left ventricular longitudinal strain and strain rate measurements in paediatric patients in long-term treatment for Chagas disease
Cardiol Young · DOI: 10.1017/S1047951121000408 · PubMed -
ChagasEnsayo clínico
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial
Lancet Infect Dis · DOI: 10.1016/S1473-3099(20)30844-6 · PubMed -
Optimization and biological validation of an in vitro assay using the transfected Dm28c/pLacZ Trypanosoma cruzi strain
Biol Methods Protoc · DOI: 10.1093/biomethods/bpab004 · PubMed -
Prediction of parasitological cure in children infected with Trypanosoma cruzi using a novel multiplex serological approach: an observational, retrospective cohort study
Lancet Infect Dis · DOI: 10.1016/S1473-3099(20)30729-5 · PubMed -
Prospective multicenter evaluation of real time PCR Kit prototype for early diagnosis of congenital Chagas disease
EBioMedicine · DOI: 10.1016/j.ebiom.2021.103450 · PubMed -
ChagasEnsayo clínico
Prospective, historically controlled study to evaluate the efficacy and safety of a new paediatric formulation of nifurtimox in children aged 0 to 17 years with Chagas disease one year after treatment (CHICO)
PLoS Negl Trop Dis · DOI: 10.1371/journal.pntd.0008912 · PubMed -
HepatopatíasRevisión
Viral hepatitis update: Progress and perspectives
World J Gastroenterol · DOI: 10.3748/wjg.v27.i26.4018 · PubMed